This may in turn pave the way for the implementation of tailored precision therapy strategies at the individual patient level. We will also discuss how comprehensive genomic characterization using broad sequencing panels, allowing for the simultaneous detection of different types of genetic aberrations, may aid future development of precision diagnostics in lymphomas. In this review, we will highlight clinically relevant diagnostic, prognostic and predictive markers in lymphomas that are used today in routine diagnostics. However, despite these efforts, there is still a limited number of gene mutations with predictive impact that can guide treatment selection. These studies have allowed better understanding of the ontogeny and evolution of different lymphomas, while also identifying new genetic markers that can complement lymphoma diagnostics and improve prognostication. chronic lymphocytic leukemia and diffuse large B cell lymphoma), indeed reflecting the great clinical heterogeneity among lymphomas. Waldenström’s macroglobulinemia and hairy cell leukemia), the vast majority demonstrated a very diverse genetic landscape with a high number of recurrent gene mutations (e.g. Whilst a few lymphoma entities were characterized by a predominant gene mutation (e.g. With the introduction of high-throughput sequencing technologies, a rapid, in-depth portrayal of the genomic landscape in major lymphoma entities was achieved. It does not store any personal data.Genetics is an integral part of the clinical diagnostics of lymphomas that improves disease subclassification and patient risk-stratification. All treatment starts with diagnosis, so Precision Diagnostics precedes and is indissociable from Precision Therapeutics. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance".
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